William A Goddard, Iii

Title: William A. Goddard, III: A Pioneer in Therapeutic Oligonucleotide Delivery

Introduction

William A. Goddard, III, based in Pasadena, California, is a renowned inventor and researcher with a remarkable portfolio of 34 patents. His innovative work primarily focuses on biotechnology, particularly in the development of oligonucleotide-based therapeutic delivery systems that have the potential to revolutionize how diseases are treated.

Latest Patents

Goddard's latest patents showcase groundbreaking advancements in the field of drug delivery. One of his notable inventions is the "Meta-stable oligonucleotides junctions for delivery of therapeutics." This patent discloses multi-way oligonucleotide junctions that deliver one or more cargo molecules to biological targets. These junctions are engineered to be stable outside cells, allowing for easy dissociation within the cellular environment to effectively release the therapeutic cargo. Additionally, this invention includes the ability to load various ligand molecules to enhance targeted delivery.

Another significant contribution is the "Programmable conditional siRNAs and uses thereof," which outlines programmable, conditionally activated small interfering RNA constructs (Cond-siRNAs). This technology utilizes a unique combination of strands to form a structure that allows for targeted activation and gene silencing upon binding to specific input strands. These innovations have far-reaching implications for therapeutic applications in genetic diseases and cancer treatment.

Career Highlights

Throughout his career, William A. Goddard, III has made substantial contributions to the field of science and technology. He has held positions at esteemed institutions such as the California Institute of Technology and City of Hope, where he has collaborated with other leading researchers to advance the understanding and application of therapeutic technologies.

Collaborations

Goddard has worked alongside notable colleagues, including Si-ping Han and Lisa Scherer, fostering an environment of innovation and collaborative research. Their combined expertise has played a critical role in the development of new therapeutic strategies that leverage the unique properties of oligonucleotides.

Conclusion

William A. Goddard, III remains a pivotal figure in the realm of biotechnology, dedicating his career to the creation and refinement of innovative therapeutic delivery systems. With 34 patents to his name, his work continues to inspire future generations of inventors and researchers, paving the way for transformative advancements in medicine and therapeutics.