The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2023
Filed:
Feb. 10, 2020
Applicants:
City of Hope, Duarte, CA (US);
California Institute of Technology, Pasadena, CA (US);
Inventors:
Guido Marcucci, Duarte, CA (US);
Ya-Huei Kuo, Duarte, CA (US);
Si-ping Han, Duarte, CA (US);
Lisa Scherer, Duarte, CA (US);
William A. Goddard, III, Pasadena, CA (US);
John Rossi, Duarte, CA (US);
Assignees:
CITY OF HOPE, Duarte, CA (US);
CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/1135 (2013.01); C12N 2310/14 (2013.01); C12N 2310/3519 (2013.01); C12N 2320/50 (2013.01);
Abstract
Disclosed herein are conditional siRNAs activatable by CBFβ-MYH11 oncogenic gene and use thereof for treating conditions such as acute myeloid leukemia (AML). The conditional siRNAs target MCL-1 or HDAC8.