The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2024
Filed:
Feb. 10, 2021
City of Hope, Duarte, CA (US);
California Institute of Technology, Pasadena, CA (US);
Si-ping Han, Duarte, CA (US);
William A. Goddard, III, Pasadena, CA (US);
Marwa Ben Haj Salah, Duarte, CA (US);
Lisa Scherer, Duarte, CA (US);
John J. Rossi, Duarte, CA (US);
Clty of Hope, Duarte, CA (US);
California Institute of Technology, Pasadena, CA (US);
Abstract
Disclosed herein are programmable, conditionally activated small interfering RNA constructs (Cond-siRNAs) and methods of making and using the same as therapeutic agents. The Cond-siRNA comprises a sensor strand, a core strand, and a guide strand, which crossover to form a sensor duplex and a RNAi duplex attached to each other to form a single structure. Upon binding an input strand to the sensor strand, the Cond-siRNA is activated and releases RNAi targeting a desired gene.