The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2024
Filed:
Jul. 14, 2018
City of Hope, Duarte, CA (US);
California Institute of Technology, Pasadena, CA (US);
Si-ping Han, Duarte, CA (US);
Marwa Ben Haj Salah, Duarte, CA (US);
Lisa Scherer, Duarte, CA (US);
William A. Goddard, Pasadena, CA (US);
John J. Rossi, Duarte, CA (US);
City of Hope, Duarte, CA (US);
California Institute of Technology, Pasadena, CA (US);
Abstract
Disclosed herein are multi-way oligonucleotide junctions for delivering one or more cargo molecules to a biological target and method of making such junctions. The oligonucleotide junctions are formed by two or more oligonucleotides and are stable outside the cell and easily dissociate inside the cell to release the cargo molecule(s). One or more cargo molecules as well as delivery ligand can be loaded to the junctions for targeted delivery. Also disclosed are nanostructures including one or more junctions attached to each other for delivering two or more cargo molecules.