Location History:
- Jamesville, NY (US) (2017)
- Sudbury, MA (US) (2018 - 2023)
Company Filing History:
13 out of 3,685 
3 out of 3,688 
Years Active: 2017-2025
Title: Innovations and Contributions of Inventor Zhengjian Li
Introduction
Zhengjian Li is a prominent inventor based in Sudbury, MA (US), known for his significant contributions to the field of protein purification and metabolic enzyme activity. With a total of 12 patents to his name, he has made remarkable advancements that have the potential to impact various scientific and industrial applications.
Latest Patents
One of Zhengjian Li's latest patents is focused on supramolecular filamentous assemblies for protein purification. This invention provides novel immunofiber compositions designed for the purification of proteins or peptides, along with simple and cost-efficient methods and systems utilizing these compositions. The immunofibers include a customized Z-33 peptide derived from Protein A, which is used to create immuno-amphiphile molecules that assemble into immunofibers in aqueous solutions, featuring bioactive epitopes on their surface and possessing peptide or protein binding capabilities.
Another significant patent addresses metabolic enzyme activity and disulfide bond reduction during protein production. This disclosure relates to the use of host cell protein biomarkers to evaluate disulfide bond reduction in compositions containing a protein of interest. The methods described predict the occurrence of disulfide bond reduction or low molecular weight protein species by measuring the expression or activity level of at least one host cell protein, providing a benchmark value associated with these occurrences. This innovation also outlines methods for producing a protein of interest by culturing host cells capable of producing it and informing downstream isolation based on host cell protein measurements.
Career Highlights
Zhengjian Li has worked with notable organizations, including Bristol-Myers Squibb Company and The Johns Hopkins University. His experience in these esteemed institutions has contributed to his expertise and the development of his innovative patents.
Collaborations
Throughout his career, Zhengjian Li has collaborated with talented individuals such as Xuankuo Xu and Yueming Qian, further enhancing his research and development efforts.
Conclusion
Zhengjian Li's contributions to the field of protein purification and metabolic enzyme activity demonstrate his innovative spirit and dedication to advancing scientific knowledge. His patents reflect a commitment to developing practical solutions that can benefit various industries.