The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 24, 2024

Filed:

Mar. 27, 2020
Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Chao Huang, Devens, MA (US);

Joseph James Perry, Devens, MA (US);

Xuankuo Xu, Devens, MA (US);

Sanchayita Ghose, Devens, MA (US);

Zhengjian Li, Devens, MA (US);

Weixin Jin, Devens, MA (US);

Assignee:

BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 30/50 (2006.01); B01D 15/32 (2006.01); B01D 15/36 (2006.01); B01D 15/38 (2006.01); B82Y 30/00 (2011.01); B82Y 35/00 (2011.01); B82Y 40/00 (2011.01); C07K 1/18 (2006.01); C07K 1/20 (2006.01); G01N 30/02 (2006.01);
U.S. Cl.
CPC ...
G01N 30/50 (2013.01); B01D 15/327 (2013.01); B01D 15/362 (2013.01); B01D 15/3804 (2013.01); C07K 1/18 (2013.01); C07K 1/20 (2013.01); B82Y 30/00 (2013.01); B82Y 35/00 (2013.01); B82Y 40/00 (2013.01); G01N 2030/027 (2013.01);
Abstract

In certain embodiments, the present invention provides a method of measuring the level of hydrophobicity of a chromatographic resin. In certain embodiments, the present invention provides a method of selecting a chromatographic resin condition for purifying a protein of interest from a mixture, wherein the protein of interest has low or no aggregation formation during chromatography. In certain embodiments, the present invention provides a method of selecting a chromatographic resin from a plurality of chromatographic resins for purifying a protein of interest from a mixture, wherein the protein of interest has low or no aggregation formation during chromatography.


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