The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2018
Filed:
Dec. 01, 2016
Applicant:
Bristol-myers Squibb Company, Princeton, NJ (US);
Inventors:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); C07K 14/705 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
C07K 14/70521 (2013.01); C12N 5/0682 (2013.01); C07K 2319/30 (2013.01); C12N 2501/39 (2013.01); C12N 2511/00 (2013.01);
Abstract
The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, preferably, but not limited to, fed-batch cell cultures. In one aspect, the methods comprise the addition of glucocorticoid compound during the culturing period. The addition of glucocorticoid compound sustain a high viability of the cultured cells, and can yield an increased end titer of protein product, and a high quality of protein product, as determined, e.g., by sialic acid content of the produced protein.