The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2023
Filed:
Dec. 22, 2017
Bristol-myers Squibb Company, Princeton, NJ (US);
Zhiqiang Chen, Hudson, MA (US);
Yueming Qian, Pepperell, MA (US);
Xuankuo Xu, Boxborough, MA (US);
Chao Huang, Shrewsbury, MA (US);
Zhijun Tan, Acton, MA (US);
Zhengjian Li, Sudbury, MA (US);
BRISTOL MYERS SQUIBB COMPANY, Princeton, NJ (US);
Abstract
In certain embodiments, the disclosure provides an IgG4 antibody comprising a heavy chain and a light chain, wherein the heavy chain comprises: (a) a modified IgG4 CH1 region having a substitution of the lysine residue at position 196; or (b) a modified IgG4 hinge region having a substitution of the serine residue at position 217, the glycine residue at position 220, the proline residue at position 224 or the proline residue at position 225. Preferably, the IgG4 antibody further comprises a substitution of the serine residue at position 228 in the heavy chain hinge region.