Company Filing History:
Years Active: 2023-2025
Title: Innovations of Zhijun Tan in Antibody Manufacturing
Introduction
Zhijun Tan is a notable inventor based in Acton, MA (US). He has made significant contributions to the field of antibody manufacturing, holding a total of 2 patents. His work focuses on improving the processes involved in the production of therapeutic antibodies.
Latest Patents
Zhijun Tan's latest patents include a method of controlling the pink color generated during antibody manufacturing. This invention aims to prevent the generation of pink color by either preventing the reduction of antibodies during manufacturing and harvest or inhibiting the conversion of cyanocobalamin (CN-Cbl) to hydroxocobalamin (HO-Cbl). The method suggests that replacing white light in the cell culture media preparation and storage areas with red light can inhibit this conversion. Additionally, the addition of peroxides to the clarified bulk at harvest can inhibit the reduction of the antibody disulfide bonds. Another significant patent is for a therapeutic immunoglobulin G4 that offers improved bioanalytical and bioprocessing properties. This patent describes an IgG4 antibody with specific modifications in the heavy chain and hinge region, enhancing its functionality.
Career Highlights
Zhijun Tan is currently employed at Bristol-Myers Squibb Company, where he continues to innovate in the field of biopharmaceuticals. His work has been instrumental in advancing the understanding and production of therapeutic antibodies.
Collaborations
Zhijun has collaborated with notable coworkers, including Cheng Du and Ameya Umesh Borwankar. Their combined expertise contributes to the innovative projects at Bristol-Myers Squibb Company.
Conclusion
Zhijun Tan's contributions to antibody manufacturing through his patents reflect his commitment to advancing biopharmaceutical technology. His innovative methods and collaborative efforts continue to impact the field positively.