Location History:
- Jiangsu, CN (2021 - 2023)
- Nanjing, CN (2019 - 2024)
Company Filing History:
6 out of 34 
1 out of 11 
1 out of 159 Years Active: 2019-2025
Title: Innovations and Contributions of Inventor Xiaoke Guo
Introduction
Xiaoke Guo is a prominent inventor based in Nanjing, China. He has made significant contributions to the field of medicinal chemistry, particularly in the development of innovative prodrugs and inhibitors. With a total of seven patents to his name, Guo's work is characterized by its focus on enhancing therapeutic efficacy through novel chemical structures.
Latest Patents
Among his latest patents is the "Hydrogen peroxide-responsive KEAP1-NRF2 ppi inhibitor prodrug." This application relates to a prodrug that responds to hydrogen peroxide, featuring a unique chemical structure. By modifying a key carboxyl pharmacophore in a Keap1-Nrf2 inhibitor with a HO-responsive thiazolidinone moiety, Guo has synthesized a novel ROS-responsive antioxidant prodrug. This prodrug can achieve targeted activation of Nrf2 while enhancing therapeutic efficacy in the body. It represents the first example of a HO-responsive prodrug suitable for oral administration, with promising clinical applications due to its druggability and high targeting ability.
Another significant patent is focused on "Compositions and methods for inhibiting phenyl triazole MLL1-WDR5 protein-protein interaction." This disclosure highlights a phenyl triazole MLL1-WDR5 protein-protein interaction inhibitor and its preparation method. Pharmacodynamics experiments have demonstrated that the compound exhibits strong inhibition activity against the MLL1-WDR5 protein-protein interaction.
Career Highlights
Xiaoke Guo has worked with notable institutions, including China Pharmaceutical University and Huyabio International, LLC. His experience in these organizations has contributed to his expertise in medicinal chemistry and innovation in drug development.
Collaborations
Guo has collaborated with esteemed colleagues such as Qidong You and Xiaoli Xu. These partnerships have further enriched his research and development efforts in the field.
Conclusion
Xiaoke Guo's innovative work in medicinal chemistry, particularly through his patents, showcases his commitment to advancing therapeutic solutions. His contributions are expected to have a lasting impact on the field and improve clinical outcomes for patients.