The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2019
Filed:
Nov. 25, 2016
China Pharmaceutical University, Nanjing, CN;
Qidong You, Nanjing, CN;
Zhengyu Jiang, Nanjing, CN;
Mengchen Lu, Nanjing, CN;
Zhiyun Chen, Nanjing, CN;
Haopeng Sun, Nanjing, CN;
Xiaojin Zhang, Nanjing, CN;
Xiaoke Guo, Nanjing, CN;
Xiaoli Xu, Nanjing, CN;
CHINA PHARMACEUTICAL UNIVERSITY, Nanjing, CN;
Abstract
Compounds of formula (I) having 1-sulfonamido-4-aryloxy as a basic backbone. A preliminary activity test showed that the compounds provide excellent interference of a binding of Nrf2 by Keap1, thereby activating Nrf2. The compounds have a potential anti-inflammatory activity and can be used to treat a plurality of inflammation-associated diseases, including chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, gastroenteritis, rheumatoid arthritis, and the like.