Location History:
- Nanjing, CN (2019 - 2022)
- Jiangsu, CN (2023)
Company Filing History:
Years Active: 2019-2025
Title: Innovations of Inventor Mengchen Lu
Introduction
Mengchen Lu is a prominent inventor based in Nanjing, China. He has made significant contributions to the field of pharmaceutical sciences, particularly in the development of innovative prodrugs aimed at enhancing therapeutic efficacy. With a total of four patents to his name, his work is paving the way for advancements in drug delivery systems.
Latest Patents
One of Mengchen Lu's latest patents is titled "Hydrogen peroxide-responsive KEAP1-NRF2 ppi inhibitor prodrug, and preparation method therefor." This invention relates to a hydrogen peroxide-responsive Keap1-Nrf2 PPI inhibitor prodrug, which has a unique chemical structure. By modifying a key carboxyl pharmacophore in a Keap1-Nrf2 inhibitor with a HO-responsive thiazolidinone moiety, he has synthesized a novel ROS-responsive antioxidant prodrug. This prodrug can achieve targeted activation of Nrf2 and enhance therapeutic efficacy in the body. It is based on the concept of ROS activation-ROS clearance therapy and is expected to be clinically applicable due to its druggability and high targeting ability.
Another significant patent is for a "Naphthalenesulfonamide compound, preparation method, and application." This invention discloses a naphthalenesulfonamide compound that can interfere with Keap1-Nrf2 binding and activate Nrf2 to relieve inflammatory damage. It has potential anti-inflammatory activity and can be used to prepare drugs for various inflammation-related diseases, including chronic obstructive pulmonary disease (COPD), Alzheimer's disease, and rheumatoid arthritis.
Career Highlights
Mengchen Lu is affiliated with China Pharmaceutical University, where he continues to conduct research and develop innovative pharmaceutical solutions. His work is characterized by a strong focus on addressing complex health issues through novel drug formulations.
Collaborations
Mengchen Lu collaborates with notable colleagues, including Qidong You and Zhengyu Jiang. Their combined expertise contributes to the advancement of research in the pharmaceutical field.
Conclusion
Mengchen Lu's innovative contributions to drug development highlight his role as a leading inventor in the pharmaceutical sciences. His patents reflect a commitment to improving therapeutic outcomes and addressing significant health challenges.