The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2023
Filed:
Apr. 13, 2020
China Pharmaceutical University, Jiangsu, CN;
Qidong You, Jiangsu, CN;
Zhengyu Jiang, Jiangsu, CN;
Yuting Liu, Jiangsu, CN;
Mengchen Lu, Jiangsu, CN;
Hongli Shao, Jiangsu, CN;
Jing Zhao, Jiangsu, CN;
Xiaoli Xu, Jiangsu, CN;
Xiaoke Guo, Jiangsu, CN;
Lei Wang, Jiangsu, CN;
CHINA PHARMACEUTICAL UNIVERSITY, Jiangsu, CN;
Abstract
Disclosed in the present invention are a naphthalenesulfonamide compound, a preparation method, and an application. The naphthalenesulfonamide compound provided by the present invention can interfere with Keap1-Nrf2 binding and activate Nrf2 to relieve inflammatory damage and improve an inflammatory microenvironment, has a potential anti-inflammatory activity, and can be used for preparing an anti-inflammatory drug for inflammatory damage of various inflammation-related diseases, including chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, intestinal Inflammations, rheumatoid arthritis, etc.