The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2025
Filed:
Mar. 22, 2019
China Pharmaceutical University, Nanjing, CN;
Qidong You, Nanjing, CN;
Xiaoke Guo, Nanjing, CN;
Weilin Chen, Nanjing, CN;
Dongdong Li, Nanjing, CN;
Jing Gu, Nanjing, CN;
Jun Xu, Nanjing, CN;
Xin Chen, Nanjing, CN;
Zhengyu Jiang, Nanjing, CN;
Xiaoli Xu, Nanjing, CN;
China Pharmaceutical University, Jiangsu, CN;
Abstract
The present disclosure discloses a WDR5 protein-protein interaction inhibitor, including a compound having a structure represented by general formula (I). Experiments show that the inhibitor acts on a WDR5 protein and an interacting protein thereof including, but not limited to, MLL, selectively inhibits the proliferation of leukemia cells, and inhibits the methylation of H3K4 and the expression of downstream Hox/Meis-1 gene at the cellular level. The present disclosure also discloses a method for preparing the inhibitor and use thereof in the preparation of a drug for treating acute leukemia and other related diseases.