Location History:
- Newton, MA (US) (2013)
- Boston, MA (US) (2021)
- Brookline, MA (US) (2013 - 2023)
Company Filing History:
12 out of 1,036 
5 out of 2,961 
2 out of 443 
Years Active: 2013-2023
Title: The Innovations of Stuart H Orkin
Introduction
Stuart H Orkin is a prominent inventor based in Brookline, MA, known for his significant contributions to the field of genomics. With a total of 13 patents to his name, he has made remarkable strides in understanding and manipulating genetic elements for therapeutic purposes. His work has had a profound impact on the treatment of various hemoglobin disorders.
Latest Patents
Among his latest patents is a groundbreaking invention titled "Functional genomics using CRISPR-Cas systems for saturating mutagenesis of non-coding elements." This application focuses on creating a deep scanning mutagenesis library that interrogates phenotypic changes in cell populations. It utilizes a plurality of CRISPR-Cas system guide RNAs targeting genomic sequences within continuous genomic regions. The guide RNAs target at least 100 genomic sequences upstream of a PAM sequence for every 1000 base pairs within the region, showcasing a novel method for genomic interrogation.
Another significant patent is "Targeting BCL11A enhancer functional regions for fetal hemoglobin reinduction." This invention provides nucleic acid molecules that target the BCL11A enhancer functional regions. It includes methods for increasing fetal hemoglobin levels in cells by disrupting BCL11A expression at the genomic level. This innovation holds promise for treating hemoglobinopathies by reinducing fetal hemoglobin levels, particularly targeting specific enhancer functional regions.
Career Highlights
Stuart H Orkin has had a distinguished career, working with notable institutions such as Children's Medical Center Corporation and Harvard College. His research has been pivotal in advancing our understanding of genetic disorders and developing innovative therapeutic strategies.
Collaborations
Throughout his career, Orkin has collaborated with esteemed colleagues, including Vijay G Sankaran and Daniel E Bauer. These partnerships have further enriched his research and contributed to the success of his innovative projects.
Conclusion
Stuart H Orkin's contributions to the field of genomics through his patents and collaborations have significantly advanced the understanding of genetic disorders. His innovative approaches continue to pave the way for new therapeutic strategies in medicine.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.