The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2023
Filed:
Sep. 17, 2019
Applicant:
The Children's Medical Center Corporation, Boston, MA (US);
Inventors:
Assignee:
THE CHILDREN'S MEDICAL CENTER CORPORATION, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/63 (2006.01); A61K 35/28 (2015.01); C12N 5/078 (2010.01); C12N 15/12 (2006.01); C12N 9/16 (2006.01); C12N 15/01 (2006.01); C07K 14/47 (2006.01); C07K 14/805 (2006.01); C12N 15/10 (2006.01); A61K 35/12 (2015.01); A61K 38/46 (2006.01); C12N 9/22 (2006.01);
U.S. Cl.
CPC ...
C12N 15/01 (2013.01); A61K 35/12 (2013.01); A61K 38/465 (2013.01); C07K 14/4702 (2013.01); C07K 14/805 (2013.01); C12N 9/22 (2013.01); C12N 15/102 (2013.01); C12N 15/63 (2013.01);
Abstract
Provided herein are methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.