The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2018
Filed:
Jan. 04, 2016
Applicants:
Children's Medical Center Corporation, Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Stuart H. Orkin, Brookline, MA (US);
Vijay G. Sankaran, Jamaica Plain, MA (US);
Assignees:
The Children's Medical Center Corporation, Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 31/70 (2006.01); C12N 5/00 (2006.01); C12N 15/113 (2010.01); A61K 31/713 (2006.01); A01K 67/027 (2006.01); C07K 14/47 (2006.01); C07K 14/805 (2006.01); C12N 15/85 (2006.01); C12N 15/86 (2006.01); A61K 35/28 (2015.01); A61K 49/00 (2006.01); C12N 5/0789 (2010.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A01K 67/0275 (2013.01); A61K 31/713 (2013.01); A61K 35/28 (2013.01); A61K 49/00 (2013.01); C07K 14/4705 (2013.01); C07K 14/805 (2013.01); C12N 5/0647 (2013.01); C12N 15/8509 (2013.01); C12N 15/86 (2013.01); A01K 2217/052 (2013.01); A01K 2217/15 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0381 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2740/15043 (2013.01); C12N 2800/206 (2013.01);
Abstract
The invention relates to methods and uses of modulating fetal hemoglobin expression (HbF) in a hematopoietic progenitor cells via inhibitors of BCL11A expression or activity, such as RNAi and antibodies.