Neeraj Jagdish Agrawal

Title: Neeraj Jagdish Agrawal: Innovator in Biotherapeutics

Introduction

Neeraj Jagdish Agrawal, based in Waltham, MA, is a prominent inventor with a remarkable portfolio of 18 patents. His innovative work focuses primarily on biotherapeutics, contributing significantly to advancements in medical science.

Latest Patents

Among his latest patents is the invention of bispecific antibodies with cleavable C-terminal charge-paired tags. This invention details a CH3-containing molecule, which includes a first polypeptide with both a CH3 domain and a negatively charged domain consisting of consecutive negatively charged amino acid residues. It also encompasses a second polypeptide containing a CH3 domain and a positively charged domain of consecutive positively charged amino acid residues. Additionally, this patent outlines methods for conjugating synthetic molecules to a multi-specific antigen binding molecule.

Another significant patent involves nucleic acid molecules encoding binding proteins for the gastric inhibitory peptide receptor (GIPR). This invention provides methods for treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide. Conditions such as type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels, and diabetic nephropathy are addressed, with certain embodiments involving administration in conjunction with a GLP-1 receptor agonist.

Career Highlights

Neeraj Agrawal has held notable positions at leading institutions such as Amgen Inc. and the Massachusetts Institute of Technology. His diverse experiences in these reputable companies have shaped his approach to research and innovation.

Collaborations

Throughout his career, Neeraj has collaborated with distinguished professionals, including Zhulun Wang and Ian Nevin Foltz. These partnerships have contributed to the success of his innovative projects and the advancement of biotherapeutic applications.

Conclusion

Neeraj Jagdish Agrawal’s extensive work and inventive patents signify his contributions to the field of biotherapeutics. His focus on developing solutions for complex metabolic diseases highlights his commitment to enhancing healthcare through innovation.