The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2024
Filed:
Apr. 27, 2018
Applicant:
Amgen Inc., Thousand Oaks, CA (US);
Inventors:
Neeraj Jagdish Agrawal, Natick, MA (US);
Pavan Ghattyvenkatakrishna, Cambridge, MA (US);
Sekhar Kanapuram, Thousand Oaks, CA (US);
Christopher James Sloey, Newbury Park, CA (US);
Assignee:
Amgen Inc., Thousand Oaks, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 9/08 (2006.01); A61K 9/19 (2006.01); A61K 31/198 (2006.01); A61K 31/401 (2006.01); A61K 31/4172 (2006.01); A61K 38/05 (2006.01); A61K 47/18 (2017.01); A61K 47/26 (2006.01); C07K 5/06 (2006.01); C07K 16/18 (2006.01); C07K 16/40 (2006.01);
U.S. Cl.
CPC ...
C07K 16/40 (2013.01); A61K 9/08 (2013.01); A61K 9/19 (2013.01); A61K 31/198 (2013.01); A61K 31/401 (2013.01); A61K 31/4172 (2013.01); A61K 38/05 (2013.01); A61K 39/3955 (2013.01); A61K 39/39591 (2013.01); A61K 47/183 (2013.01); A61K 47/26 (2013.01); C07K 5/06 (2013.01); C07K 16/18 (2013.01);
Abstract
Provided herein are excipients capable of effectively reducing the viscosity of polypeptide (e.g., therapeutic polypeptide) formulations. The viscosity reducing excipients are dipeptides containing arginine at the carboxy terminus and N-acetylated serine or N-acetylated proline at the N-terminus. Glutamate-arginine is also disclosed as a viscosity-reducing dipeptide. Among the disclosed methods, methods of reducing the viscosities of such formulations are also provided.