The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2025
Filed:
May. 08, 2019
Amgen Inc., Thousand Oaks, CA (US);
John K. Kawooya, Moorpark, CA (US);
Alex W. Jacobitz, Thousand Oaks, CA (US);
Christopher Mohr, Newbury Park, CA (US);
Stephen Smith, Newbury Park, CA (US);
Kevin Graham, Thousand Oaks, CA (US);
Ray Lieh Yoon Low, Redwood City, CA (US);
Oliver Thiel, Lexington, MA (US);
Dante Romanini, Sherman Oaks, CA (US);
Victoria Wagner, Simi Valley, CA (US);
Neeraj J. Agrawal, Natick, MA (US);
AMGEN INC., Thousand Oaks, CA (US);
Abstract
The present invention is directed to a CH3-containing molecule comprising (a) a first polypeptide comprising a CH3 domain and a negatively charged domain comprising consecutive negatively charged amino acid residues; and (b) a second polypeptide comprising a CH3 domain and a positively charged domain comprising consecutive positively charged amino acid residues. Also provided are methods for conjugating synthetic molecules to a multi-specific antigen binding molecule.