The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2024
Filed:
Jun. 11, 2021
Amgen Inc., Thousand Oaks, CA (US);
Joon Hoi Huh, Culver City, CA (US);
Riki Stevenson, Ventura, CA (US);
Pavel Bondarenko, Thousand Oaks, CA (US);
Andrew Nichols, Calabasas, CA (US);
Da Ren, Thousand Oaks, CA (US);
Neeraj Jagdish Agrawal, Natick, MA (US);
Richard Smith, Belmont, CA (US);
AMGEN INC., Thousand Oaks, CA (US);
Abstract
The present invention concerns a method for preparing antigen binding proteins specific for PCSK9 with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.