Da Ren

Title: The Innovations of Da Ren

Introduction

Da Ren is an accomplished inventor based in Thousand Oaks, CA (US). He holds a total of 6 patents that showcase his expertise in the field of biochemistry and protein analysis. His innovative approaches have contributed significantly to the development of therapeutic polypeptides and antigen binding proteins.

Latest Patents

One of Da Ren's latest patents is titled "Sequential digestion of polypeptides for mass spectrometric analysis." This invention outlines methods for preparing polypeptides for multi-attribute analysis, which includes denaturing, reducing, and alkylating the polypeptides before subjecting them to a first digestion. The resulting fragments are then separated and analyzed using various methods, making this technique particularly useful for therapeutic polypeptides that are challenging to cleave.

Another notable patent is "Low-viscosity antigen binding proteins and methods of making them." This invention focuses on preparing antigen binding proteins specific for PCSK9 with reduced viscosity. The method involves replacing residues in high viscosity variable domain subfamilies with those from low viscosity subfamilies, as well as modifying the Fc domain to enhance its properties. This innovation has the potential to improve the efficacy of therapeutic proteins.

Career Highlights

Throughout his career, Da Ren has worked with prominent companies, including Amgen Inc. His contributions to the field have been recognized through his patents and the impact of his work on therapeutic developments.

Collaborations

Da Ren has collaborated with notable professionals in his field, including Joon Hoi Huh and Riki Stevenson. These collaborations have further enriched his research and innovations.

Conclusion

Da Ren's contributions to the field of biochemistry through his patents and collaborations highlight his role as a significant inventor. His work continues to influence the development of therapeutic proteins and methods for protein analysis.