The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2021
Filed:
Jun. 07, 2018
Purdue Research Foundation, West Lafayette, IN (US);
Amgen Inc., Thousand Oaks, CA (US);
Stephen T. Ayrton, West Lafayette, IN (US);
Robert Graham Cooks, West Lafayette, IN (US);
Tawnya Flick, Thousand Oaks, CA (US);
Da Ren, Thousand Oaks, CA (US);
Purdue Research Foundation, West Lafayette, IN (US);
AMGEN INC., Thousand Oaks, CA (US);
Abstract
The invention generally relates to methods for determining whether a peptide includes aspartate or isoaspartate. In certain aspects, methods of the invention involve binding an aspartate/isoaspartate residue in a peptide with a label to produce a labeled peptide. The labeled peptide is then ionized. The ionizing process causes the label to undergo rearrangement in a gas phase at a higher rate if the label is bound to the aspartate residue as compared to if the label is bound to the isoaspartate residue. The methods of the invention then involve performing a mass spectrometry analysis to detect the rearrangement of the label, thereby determining whether the peptide includes aspartate or isoaspartate.