The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2022
Filed:
Sep. 05, 2014
Amgen Inc., Thousand Oaks, CA (US);
Zhimei Du, Bellvue, WA (US);
Pranhitha Reddy, Seattle, WA (US);
Randal B. Bass, Seattle, WA (US);
Feng He, Lynnwood, WA (US);
William C. Fanslow, III, Normandy Park, WA (US);
Yuling Zhang, Bellevue, WA (US);
Da Ren, Thousand Oaks, CA (US);
Randal R. Ketchem, Snohomish, WA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The present invention relates to variant Fc-containing molecules, such as antibodies and Fc-fusion molecules, having glycosylation characteristics favorable to largescale production of therapeutic molecules containing such variant Fc. Described herein are compositions and methods to improve glycosylation maturation of and to minimize the culture process-dependent effects of Fc-containing molecules, e.g., Fc-fusion molecules and antibodies. Creating single and multiple amino acid substitutions within the Fc domain with the aim to improve high mannose processing and glycosylation maturation.