Feng He

Title: Innovations by Feng He in Glycoform Profiles

Introduction

Feng He is an accomplished inventor based in Lynnwood, WA (US). He has made significant contributions to the field of biotechnology, particularly in the development of Fc-containing molecules. His work focuses on improving glycosylation characteristics, which are crucial for the large-scale production of therapeutic molecules.

Latest Patents

Feng He holds a patent for "Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles." This invention relates to variant Fc-containing molecules, such as antibodies and Fc-fusion molecules, which possess glycosylation characteristics favorable for therapeutic applications. The patent describes compositions and methods aimed at enhancing glycosylation maturation and minimizing culture process-dependent effects of these molecules. The invention includes creating single and multiple amino acid substitutions within the Fc domain to improve high mannose processing and glycosylation maturation.

Career Highlights

Feng He is currently employed at Amgen Inc., a leading biotechnology company known for its innovative therapies. His work at Amgen has allowed him to contribute to advancements in the production of therapeutic proteins, enhancing their efficacy and safety.

Collaborations

Feng has collaborated with notable colleagues, including Zhimei Du and Pranhitha Reddy. These collaborations have fostered a productive environment for innovation and research in the field of biotechnology.

Conclusion

Feng He's contributions to the development of Fc-containing molecules have the potential to significantly impact the biotechnology industry. His innovative approaches to glycosylation maturation are paving the way for more effective therapeutic solutions.