Amgen Inc.

Feng He

Randal Robert Ketchem

William C Fanslow, Iii

Pranhitha Reddy

Da Ren

Randal B Bass

Yuling Zhang

Zhimei Du

The present invention relates to variant Fc-containing molecules, such as antibodies and Fc-fusion molecules, having glycosylation characteristics favorable to largescale production of therapeutic molecules containing such variant Fc. Described herein are compositions and methods to improve glycosylation maturation of and to minimize the culture process-dependent effects of Fc-containing molecules, e.g., Fc-fusion molecules and antibodies. Creating single and multiple amino acid substitutions within the Fc domain with the aim to improve high mannose processing and glycosylation maturation.

Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles

Growing community of inventors

Lynnwood, WA, United States of America

Feng He