The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2024
Filed:
Oct. 07, 2020
Amgen Inc., Thousand Oaks, CA (US);
Eric Alan Butz, Seattle, WA (US);
Christy Ann Thomson, Port Moody, CA;
Marc Alain Gavin, Seattle, WA (US);
Ian Nevin Foltz, Burnaby, CA;
Dong Xia, Redmond, WA (US);
Dina N. Alcorn, Tacoma, WA (US);
Randal Robert Ketchem, Snohomish, WA (US);
Ai Ching Lim, San Carlos, CA (US);
Kathy Manchulenko, Port Coquitlam, CA;
Laura Sekirov, Vancouver, CA;
Kelly Ann Berry, Port Coquitlam, CA;
Cyr Clovis Chua De Imus, Kenmore, WA (US);
Neeraj Jagdish Agrawal, Natick, MA (US);
Gunasekaran Kannan, Daly City, CA (US);
Li Li, San Bruno, CA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.