Location History:
- Shanghai, CN (2013 - 2024)
- Suzhou, CN (2024)
Company Filing History:
4 out of 65 
2 out of 7 
2 out of 54 
Years Active: 2013-2025
Title: Innovations in Base Editing: The Patents of Jia Chen
Introduction: Jia Chen, an innovative inventor based in Shanghai, China, holds a remarkable portfolio of seven patents. His research primarily focuses on the groundbreaking field of base editing, an area of genetic engineering that allows for precise modifications in DNA sequences.
Latest Patents: Among his latest contributions to the field are two significant patents. The first is titled "Fusion proteins for improved precision in base editing," which introduces base editors containing a cytidine and a catalytically inactive version of Lachnospiraceae bacterium Cpf1 (LbCpf1). These new base editors demonstrate significantly improved editing efficiency and fidelity compared to traditional Cas9-based editors, featuring unique editing windows. The second patent, "Fusion proteins for base editing," outlines fusion proteins that incorporate an apolipoprotein B mRNA editing enzyme catalytic subunit 3A (APOBEC3A) along with a CRISPR-associated (Cas) protein, and optionally includes a uracil glycosylase inhibitor (UGI). This innovative fusion protein can edit DNA by deaminating cytosine to uracil, even when cytosine is part of a GpC context or is methylated.
Career Highlights: Jia Chen’s career has been marked by his association with reputable institutions and companies. Notably, he has contributed to research and development at ShanghaiTech University and Analog Devices, Inc., where his work has fostered advancements in genetic engineering and biotechnology.
Collaborations: Collaboration has been a key aspect of Jia Chen's success. He has worked alongside esteemed colleagues such as Li Yang and Xingxu Huang, leveraging their expertise to enhance his contributions to the field of base editing.
Conclusion: With a strong foundation in research and a focus on innovation, Jia Chen continues to push the boundaries of genetic engineering. His patents not only represent significant advancements in base editing technology but also pave the way for future developments in the realm of genetic modification and biotechnology.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.