The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2024
Filed:
Feb. 22, 2019
Applicant:
Shanghaitech University, Pudong New Area, CN;
Inventors:
Assignee:
ShanghaiTech University, Shanghai, CN;
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/78 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01); C12N 15/90 (2006.01); C12N 15/01 (2006.01);
U.S. Cl.
CPC ...
C12N 9/78 (2013.01); C12N 9/22 (2013.01); C12N 15/01 (2013.01); C12N 15/907 (2013.01); C12Y 305/04 (2013.01); C07K 2319/00 (2013.01); C12N 2310/20 (2017.05); C12N 2800/80 (2013.01);
Abstract
Provided are fusion proteins that include an apolipoprotein B mRNA editing enzyme catalytic subunit 3A (APOBEC3A) and a clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) protein, optionally further with uracil glycosylase inhibitor (UGI). Such a fusion protein is able to conduct base editing in DNA by deaminating cytosine to uracil, even when the cytosine is in a GpC context or is methylated.