Shanghaitech University

Zhejiang Huahai Pharmaceutical Co., Ltd.

Shanghai Synergy Pharmaceutical Sciences Co., Ltd.

Intel Corporation

Siemens Aktiengesellschaft

Analog Devices,inc.

State Grid Shanghai Municipal Electric Power Company

Jia Chen

Li Yang

Xingxu Huang

Bei Yang

Xin Xu

Zhen Zhang

Yunfei Li

Jian Ge

Yijin Wang

Xiaoer Xia

Xiaojuan Zhang

Qiang Li

Fan Wang

Jun Ye

Fan Yang

Ye Zhang

Bin Shao

Liang Zhang

Lijie Wang

Guan Zhong Wang

Ting Ye

Hao Yu

Cong Chao Li

Xiao Wang

Ying Wang

Xiaobo Zhou

Qingyun Jiang

Kang Sun

Lijun Zhou

Peng Wei Tian

Yajing Liu

Cheng Feng

Liming Zhang

Yin Zhou

Wanggen Liu

Linli Zhang

Fengying Guo

Chenbin Wu

Yunjie Zhou

Xiaojuan Jiang

Hong Min

Tiecheng Lou

Xiaosa Li

Jinhua Yu

Chenghao Xi

Chunqiao Chen

Kaibo Ma

Yuyun Zhang

Dekang Wen

Minkai Qu

Qimei Wu

Qinqin Han

Chengxu Zang

Jianan Li

Ran An

Tianyu Yang

Chenyang Xuan

Stefan Höhe

Ping Ping Jin

Zhang Yao Bao

Provided are amide compounds, a preparation method therefor, and use thereof in the medical field. Specifically, provided are small molecule amide compounds. Such compounds are inhibitors of enhancer of Zeste homolog 2 (EZH2), and can be used for preventing and/or treating related diseases mediated by EZH2, including tumors, myeloproliferative diseases or autoimmune diseases.

Amide compounds, preparation method therefor, and use thereof in the medical field

Related are a JAK kinase inhibitor, a preparation method for same, and applications thereof in the field of medicine, related to the field of medicinal chemistry. Provided is a novel small molecule JAK inhibitor, which has the structure as represented by formula (II). The compound provides improved efficacy and safeness in preventing or treating a JAK-related indication.

JAK kinase inhibitor, preparation method for same, and applications thereof in field of medicine

Provided are base editors containing a cytidine and a catalytically inactive version of Lachnospiraceae bacterium Cpf1 (LbCpf1). The new base editors have greatly improved editing efficiency and fidelity as compared to Cas9-based base editors, and have different editing windows.

Fusion proteins for improved precision in base editing

Various embodiments of the teachings herein include anomaly detection methods for a dynamic control system. An example method includes: using a g network to initialize a hidden state distribution of the system; receiving a measurement value of a sensor and a state value of a trigger at a current point of time; receiving a sampling point into an f network to perform a prediction to obtain a second sampling point; using an h network to map the second sampling point into a sensor measurement value space to perform a prediction to obtain a probability distribution of a measurement value of the sensor in the dynamic control system at the current point of time; and determining whether an anomaly exists in the dynamic control system by comparing the measurement value obtained from real-time monitoring and the probability distribution obtained from a prediction.

Anomaly detection method and apparatus for dynamic control system, and computer-readable medium

Provided are fusion proteins that include an apolipoprotein B mRNA editing enzyme catalytic subunit 3A (APOBEC3A) and a clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) protein, optionally further with uracil glycosylase inhibitor (UGI). Such a fusion protein is able to conduct base editing in DNA by deaminating cytosine to uracil, even when the cytosine is in a GpC context or is methylated.

Fusion proteins for base editing

Provided are fusion proteins and related molecules useful for conducting base editing with reduced or no off-target mutations. The fusion protein may include a first fragment comprising a nucleobase deaminase or a catalytic domain thereof, a second fragment comprising a nucleobase deaminase inhibitor, and a protease cleavage site between the first fragment and the second fragment. Also provided are improved prime editing systems, including prime editing guide RNA with improved stability.

Inhibition of unintended mutations in gene editing

Provided are fusion proteins and related molecules useful for conducting base editing with reduced or no off-target mutations. The fusion proteins may include a first fragment comprising a nucleobase deaminase or a catalytic domain thereof, a second fragment comprising a nucleobase deaminase inhibitory domain, and a protease cleavage site between the first fragment and the second fragment. Also provided are improved prime editing systems, including prime editing guide RNA with improved stability.

A warning device for preventing underground cables against accidental excavation comprises an optical fiber vibration sensor having a mode recognition function, a signal processing unit, a wireless communication unit and a power supply unit, wherein the signal processing unit is connected to the optical fiber vibration sensor, the wireless communication unit and the power supply unit, and the optical fiber vibration sensor is installed within a set range of a cable and is used to monitor vibration signals around the cable, so that once a behavior possibly endangering the cable occurs, an alarm is given out in time to reduce power transmission and transformation accidents. Compared with the prior art, the warning device has the advantages of low false alarm rate, rapid response and accurate localization region.

Warning device for preventing underground cables against accidental excavation

A method, device, and system are disclosed. In one embodiment the method includes determining a current computing-memory ratio. Then the method compares the current computing-memory ratio to a lower ratio threshold value. Then the method configures a next draw command to be performed using a graphics memory efficiency operational mode when the current computing-memory ratio is below the lower ratio threshold value.

Graphics pipeline scheduling architecture utilizing performance counters

Switching voltage regulator embodiments are provided with hysteretic control to thereby switch between pulse-width modulation and pulse-frequency modulation operational modes. The switching is in response to different levels of an error voltage Vin the feedback loop of voltage regulators. The hysteretic control is configured to provide a dc hysteretic response to changes in the error voltage Vand also an ac hysteretic response to these changes. These two responses can be independently set to thereby enhance operational speed of the voltage regulators and also enhance immunity to transient noise signals that are generated by the mode switching. The voltage regulator embodiments facilitate instant return from the pulse-frequency modulation operational mode to the pulse-width modulation operational mode so that the stability of the feedback control of the regulator is enhanced. This feature is especially useful when the feedback loop is configured to include current-mode control as it minimizes the time duration in which the feedback loop operates in a voltage-mode control. The instant return insures that the feedback loop is immediately returned to the greater stability of the current-mode control.

Switching voltage regulators with hysteretic control for enhanced mode-transition speed and stability

Growing community of inventors

Shanghai, China

Jia Chen