The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 2023
Filed:
Jul. 11, 2022
Applicant:
Shanghaitech University, Shanghai, CN;
Inventors:
Jia Chen, Shanghai, CN;
Bei Yang, Shanghai, CN;
Li Yang, Shanghai, CN;
Xingxu Huang, Shanghai, CN;
Lijie Wang, Shanghai, CN;
Assignee:
ShanghaiTech University, Shanghai, CN;
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C12N 9/22 (2006.01); C12N 9/50 (2006.01); C12N 9/78 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 15/102 (2013.01); C12N 9/22 (2013.01); C12N 9/506 (2013.01); C12N 9/78 (2013.01); C12N 15/111 (2013.01); C07K 2319/50 (2013.01); C07K 2319/85 (2013.01); C12N 2310/20 (2017.05); C12Y 304/22044 (2013.01); C12Y 305/04004 (2013.01); C12Y 305/04005 (2013.01);
Abstract
Provided are fusion proteins and related molecules useful for conducting base editing with reduced or no off-target mutations. The fusion protein may include a first fragment comprising a nucleobase deaminase or a catalytic domain thereof, a second fragment comprising a nucleobase deaminase inhibitor, and a protease cleavage site between the first fragment and the second fragment. Also provided are improved prime editing systems, including prime editing guide RNA with improved stability.