This inventor holds 46 USPTO granted patents and 5 published patent applications and 5 EPO patents, primarily in Transcriptome Analysis. Top assignees: University of Pennsylvania, Leland Stanford Junior University, Agilent Technologies, Inc.. Active years: 1991-2026.
Location History:
- Menlo Park, CA (US) (1991 - 1992)
- Belcamp, MD (US) (1998 - 1999)
- Philadelphia, PA (US) (1996 - 2024)
Company Filing History:
36 out of 2,645Â 
5 out of 5,489Â 
1 out of 4,728Â Years Active: 1991-2026
Areas of Expertise:
Title: Innovations of James H. Eberwine: Pioneering Advances in Gene Analysis
Introduction
James H. Eberwine, based in Philadelphia, PA, is a distinguished inventor with an impressive portfolio of 44 patents. His groundbreaking work primarily focuses on molecular biology, particularly in the field of genomics and transcriptomics. Eberwine's innovations have significantly contributed to understanding gene expression at the single-cell level, with vital implications in research and medicine.
Latest Patents
Among Eberwine's latest patents are two remarkable inventions: Transcriptome in vivo analysis (TIVA) and transcriptome in situ analysis (TISA). These compositions and methods facilitate the capture of one or more nucleic acid molecules from a cell or subcellular compartment. The innovative compositions include a caged molecule featuring photolinkers and an antisense oligonucleotide, which, upon activation, hybridizes with the target nucleic acid. Furthermore, Eberwine has developed compositions and methods for genomic DNA and gene expression analysis in single cells. These novel methodologies allow for comprehensive assessments of the genomic landscape of fixed cells by utilizing light-activated oligonucleotides. This technology enables targeted assessments in the nucleus, mitochondria, or cytoplasm and supports the in situ copying of nuclear single-stranded DNA and cytoplasmic RNA into barcoded complementary DNA. This innovation provides insights into gene-specific 3D chromatin structural niche analysis.
Career Highlights
James H. Eberwine has had a fruitful career, contributing his expertise to renowned institutions such as the University of Pennsylvania and Stanford University. His work in these prestigious establishments has advanced our collective understanding of molecular biology and developed methodologies pivotal for research in gene expression and cellular functions.
Collaborations
Throughout his career, Eberwine has had the pleasure of collaborating with esteemed colleagues, including Jai-Yoon Sul and Jack D. Barchas. These partnerships have amplified the impact and reach of his innovations, fostering a collaborative spirit in the realm of scientific inquiry.
Conclusion
In conclusion, James H. Eberwine's contributions to the field of molecular biology and genomics are invaluable. His latest patents demonstrate a commitment to advancing our understanding of gene expression and analysis at the cellular level. With a remarkable career and a legacy of innovation, Eberwine continues to inspire future generations of scientists and inventors.