The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2023
Filed:
Jan. 07, 2020
Agilent Technologies, Inc., Santa Clara, CA (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
James Eberwine, Philadelphia, PA (US);
Jae-Hee Lee, Philadelphia, PA (US);
Jifen Li, Philadelphia, PA (US);
Stephen Fisher, Philadelphia, PA (US);
Youtao Lu, Philadelphia, PA (US);
Junhyong Kim, Philadelphia, PA (US);
Jai-Yoon Sul, Philadelphia, PA (US);
Jinchun Wang, Santa Clara, CA (US);
Mimi Healy, Santa Clara, CA (US);
Agilent Technologies, Inc., Santa Clara, CA (US);
Abstract
Provided herein are compositions and methods to assess the genomic landscape of fixed cells using light activated oligonucleotides that can be directed to the nucleus, mitochondria, or cytoplasm of fixed cells and that, upon activation, can be extended for in situ copying of nuclear single-stranded DNA (i.e., open chromatin), open mitochondrial DNA, and/or cytoplasmic RNA into barcoded complementary DNA. These methods also provide for gene specific 3D chromatin structural niche analysis.