The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 16, 2024

Filed:

May. 28, 2021
Applicant:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Inventors:

James Eberwine, Philadelphia, PA (US);

Ivan J. Dmochowski, Philadelphia, PA (US);

Sean B. Yeldell, Philadelphia, PA (US);

Julianne C. Griepenburg, Philadelphia, PA (US);

Teresa L. Rapp, Philadelphia, PA (US);

Jennifer M. Singh, Havertown, PA (US);

Jai-Yoon Sul, Cherry Hill, NJ (US);

Jaehee Lee, Wynnewood, PA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6823 (2018.01); C12Q 1/6825 (2018.01); C12Q 1/6818 (2018.01); C07F 15/00 (2006.01); C12N 15/113 (2010.01); C07H 23/00 (2006.01); C12N 13/00 (2006.01); B01J 35/00 (2006.01);
U.S. Cl.
CPC ...
C07F 15/0053 (2013.01); B01J 35/004 (2013.01); C07H 23/00 (2013.01); C12N 13/00 (2013.01); C12N 15/113 (2013.01); C12Q 1/6818 (2013.01); C12Q 1/6823 (2013.01); C12Q 1/6825 (2013.01); B01J 2531/821 (2013.01); C12N 2310/11 (2013.01); C12N 2310/32 (2013.01); C12N 2310/3233 (2013.01); C12N 2310/351 (2013.01); C12N 2310/3517 (2013.01); C12N 2310/531 (2013.01);
Abstract

Compositions and methods of capturing one or more nucleic acid molecules of a cell or subcellular compartment are described. In certain aspects, the compositions comprise a caged molecule comprising one or more photolinkers and an antisense oligonucleotide, which when uncaged hybridizes to a target nucleic acid molecule.


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