Hitto Kaufmann

Title: **Hitto Kaufmann: Innovator in Cell Culture Technology**

Introduction

Hitto Kaufmann, a prominent inventor based in Ulm, Germany, has made significant contributions to the field of cell culture technology. With a total of seven patents to his name, Kaufmann is recognized for his innovative approaches that enhance the efficiency of protein production.

Latest Patents

Among Kaufmann's latest inventions are two notable patented technologies related to CHO/CERT cell lines. The first invention focuses on production host cell lines that incorporate vector constructs featuring a CERT S132A expression cassette. These specialized cell lines demonstrate improved growth characteristics and elevated CERT S132A expression levels. Specifically, two cell lines have been deposited with the DSMZ under the numbers DSM ACC2989 (CHO/CERT 2.20) and DSM ACC2990 (CHO/CERT 2.41). Additionally, Kaufmann has developed a method for generating these preferred production host cells and a technique for protein production utilizing these two specific cell lines.

Another significant patent involves production host cell lines that include a DHFR expression cassette. These cell lines also exhibit enhanced growth characteristics compared to DHFR-deficient or DHFR-reduced lines, such as CHO DG44 and CHO DUKX-B11. Two representative cell lines have been deposited with the DSMZ under the numbers DSM ACC2909 (CHOpper® Discovery) and DSM ACC2910 (CHOpper® Standard). This invention also includes a method for producing proteins using the developed cell lines.

Career Highlights

Throughout his career, Hitto Kaufmann has worked with esteemed organizations, including Boehringer Ingelheim Pharma GmbH & Co. KG and Boehringer Ingelheim International GmbH. His expertise and dedication have propelled advancements in cell culture methodologies.

Collaborations

Kaufmann has collaborated with talented individuals in the field, notably Lore Florin and Eric Becker. Their partnerships have fostered innovative solutions, contributing to Kaufmann's successful research and development efforts.

Conclusion

Hitto Kaufmann exemplifies innovation in the area of cell culture technology, holding several patents that reflect his dedication and expertise. His work not only enhances the production of vital proteins but also represents ongoing advancements in biotechnological processes. As the field continues to evolve, Kaufmann's contributions will undoubtedly play a pivotal role in shaping future developments.