The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2012
Filed:
Feb. 29, 2008
Hitto Kaufmann, Ulm, DE;
Lore Florin, Biberach, DE;
Eric Becker, Hochdorf, DE;
Monilola Olayioye, Ulm, DE;
Angelika Hausser, Stuttgart, DE;
Tim Fugmann, Zurich, CH;
Hitto Kaufmann, Ulm, DE;
Lore Florin, Biberach, DE;
Eric Becker, Hochdorf, DE;
Monilola Olayioye, Ulm, DE;
Angelika Hausser, Stuttgart, DE;
Tim Fugmann, Zurich, CH;
Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, DE;
Abstract
The invention concerns the field of protein production and cell culture technology. CERT is identified as a novel in vivo PKD substrate. Phosphorylation on serine 132 by PKD decreases the affinity of CERT towards its lipid target phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity, identifying PKD as a regulator of lipid homeostasis. The present invention shows that CERT in turn is critical for PKD activation and PKD dependent protein cargo transport to the plasma membrane. The interdependence of PKD and CERT is thus a key to the maintenance of Golgi membrane integrity and secretory transport.