Daryl A Guthrie

Title: Contributions of Daryl A. Guthrie to the Field of Pharmaceutical Innovations

Introduction

Daryl A. Guthrie is a prominent inventor based in Baltimore, MD, known for his significant contributions to pharmaceutical sciences. With a total of six patents to his name, he is recognized for his innovative approach to developing compounds that address various health conditions.

Latest Patents

Among Daryl A. Guthrie's latest patents are two key innovations. The first patent involves O-substituted hydroxamic acids with carbon-based leaving groups that act as HNO donors. This invention also includes pharmaceutical compositions and kits that utilize these compounds, along with methods for their application.

The second of his recent patents focuses on Meldrum's acid, barbituric acid, and pyrazolone derivatives substituted with hydroxylamine as HNO donors. This collection of N-substituted hydroxylamine derivative compounds, along with their corresponding pharmaceutical compositions and kits, aims at providing effective treatment for a range of diseases. These conditions include cardiovascular diseases, ischemia, reperfusion injury, cancerous diseases, pulmonary hypertension, and ailments responsive to nitroxyl therapy.

Career Highlights

Daryl A. Guthrie has had a fruitful career with notable experiences at respected institutions. He has contributed significantly while working at The Johns Hopkins University, a renowned research institution, and Cardioxyl Pharmaceuticals, Inc., where he further honed his expertise in pharmaceutical innovations.

Collaborations

Throughout his career, Daryl A. Guthrie has collaborated with distinguished colleagues, including John P. Toscano and Vincent Jacob Kalish. These partnerships have facilitated the advancement of research and development in the areas of his patented innovations.

Conclusion

Daryl A. Guthrie has made noteworthy contributions to the field of pharmaceuticals through his inventive work. His patents, emphasizing novel compounds and pharmaceutical compositions, not only showcase his creativity and expertise but also hold the potential to address significant health challenges. His engagements in academia and industry reflect a commitment to advancing medical science and improving patient outcomes.