The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 20, 2017

Filed:

May. 26, 2015
Applicants:

Cardioxyl Pharmaceuticals, Inc., Chapel Hill, NC (US);

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Vincent Jacob Kalish, Annapolis, MD (US);

Frederick Arthur Brookfield, Abingdon, GB;

Stephen Martin Courtney, Abingdon, GB;

Lisa Marie Frost, Abingdon, GB;

John P. Toscano, Glen Arm, MD (US);

Daryl A. Guthrie, Baltimore, MD (US);

Carl Leslie North, Abingdon, GB;

Assignees:

Cardioxyl Pharmaceuticals, Inc., Chapel Hill, NC (US);

The Johns Hopkins University, Baltimore, MD (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 231/46 (2006.01); C07D 231/56 (2006.01); C07D 401/04 (2006.01); C07D 405/04 (2006.01); C07D 413/04 (2006.01); C07D 491/048 (2006.01); C07D 491/052 (2006.01); A61K 31/4152 (2006.01); A61P 9/00 (2006.01); C07D 403/04 (2006.01); C07D 401/10 (2006.01); C07D 409/04 (2006.01); C07D 491/044 (2006.01);
U.S. Cl.
CPC ...
C07D 231/46 (2013.01); C07D 231/56 (2013.01); C07D 401/04 (2013.01); C07D 401/10 (2013.01); C07D 403/04 (2013.01); C07D 405/04 (2013.01); C07D 409/04 (2013.01); C07D 413/04 (2013.01); C07D 491/044 (2013.01); C07D 491/048 (2013.01); C07D 491/052 (2013.01);
Abstract

The disclosed subject matter provides pyrazolone derivative compounds, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.


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