For the Inventor, By the Inventor

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Chapel Hill, NC, United States of America

Cardioxyl Pharmaceuticals, Inc.

Calculating rank

USPTO Granted Patents = 37

% Expired Patents = 5.4

EPO Patents = 14

Forward Citations = 396

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11 inventors (with patents filed for the assignee):

Vincent Jacob Kalish (37 out of 52 patents)

Frederick Arthur Brookfield (37 out of 64 patents)

Stephen Martin Courtney (37 out of 52 patents)

4. Lisa Marie Frost (37 out of 37 patents)

5. John P Toscano (31 out of 44 patents)

6. Andrew D Cohen (14 out of 14 patents)

7. John Reardon (3 out of 3 patents)

8. Carl Leslie North (2 out of 6 patents)

9. Art Sutton (2 out of 2 patents)

10. Daryl A Guthrie (1 out of 6 patents)

11. Matthew Robert Conroy (1 out of 1 patent)

12. Reza Mazhari (8 patents)

Core Competencies:

Nitroxyl Donors

Pharmaceutical Compositions

N-Hydroxylsulfonamide Derivatives

Pyrazolone Derivatives

Bis-Acylated Hydroxylamine Derivatives

Nitroso Compounds

Therapeutic Index

Physiologically Useful

37 patents: Sort by Forward Citations

1. 12186301 - Nitroxyl donors with improved therapeutic index (2025-01-07),

2. 11786501 - Nitroxyl donors with improved therapeutic index (2023-10-17),

3. 11306056 - N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors (2022-04-19),

4. 11304924 - Pharmaceutical compositions comprising nitroxyl donors (2022-04-19),

5. 11273143 - Nitroxyl donors with improved therapeutic index (2022-03-15),

6. 10829445 - N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors (2020-11-10),

7. 10792273 - Nitroxyl donors with improved therapeutic index (2020-10-06),

8. 10730828 - N-hydroxylsulfonamide derivatives as nitroxyl donors (2020-08-04),

9. 10723704 - Pyrazolone derivatives as nitroxyl donors (2020-07-28),

10. 10548872 - Pharmaceutical compositions comprising nitroxyl donors (2020-02-04),

11. 10517847 - Nitroxyl donors with improved therapeutic index (2019-12-31),

12. 10487049 - N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors (2019-11-26),

13. 10245249 - Pharmaceutical compositions comprising nitroxyl donors (2019-04-02),

14. 10213408 - Nitroxyl donors with improved therapeutic index (2019-02-26),

15. 10179765 - N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors (2019-01-15),

Company Overview

Cardioxyl Pharmaceuticals, Inc. is a biotechnology company based in Chapel Hill, North Carolina, focused on developing innovative therapies for cardiovascular diseases. The company specializes in the research and development of novel compounds aimed at improving heart function and addressing unmet medical needs in the cardiovascular space. With a commitment to advancing healthcare solutions, Cardioxyl leverages cutting-edge science to create impactful treatments that enhance patient outcomes and quality of life.

Profile summary synthesized from public USPTO records and patent filings.

Company Badge

USPTO Data Jan 1 1976 - Oct 27 2026

37 Patents

#2 in Chapel Hill, NC

#219 in North Carolina

#9,276 in US

#18,312 in the World

Chapel Hill, NC, United States of America

Cardioxyl Pharmaceuticals, Inc.

Forward Citations = 396

11 inventors:

Vincent Jacob Kalish (37 out of 52 patents)

Frederick Arthur Brookfield (37 out of 64 patents)

Stephen Martin Courtney (37 out of 52 patents)

4. Lisa Marie Frost (37 out of 37 patents)

5. John P Toscano (31 out of 44 patents)

IDiyas Innovation Intelligence. (2026). Company Patent Portfolio: Cardioxyl Pharmaceuticals, Inc.. Retrieved from https://idiyas.com/company/cardioxyl-pharmaceuticals

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Data Sources: USPTO Patent Grant XML, Patent Center, EPO & CIPO • Normalized by IDiyas Innovation Graph. Methodology & provenance architecturePlease report any incorrect information to [email protected]

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