The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 04, 2020

Filed:

Oct. 18, 2016
Applicants:

Cardioxyl Pharmaceuticals, Inc., Chapel Hill, NC (US);

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Vincent Jacob Kalish, Annapolis, MD (US);

Lisa Marie Frost, Abingdon, GB;

Frederick Arthur Brookfield, Abingdon, GB;

Stephen Martin Courtney, Abingdon, GB;

John P. Toscano, Glen Arm, MD (US);

Assignees:

Cardioxyl Pharmaceuticals, Inc., Chapel Hill, NC (US);

The Johns Hopkins University, Baltimore, MD (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C 311/48 (2006.01); C07D 213/71 (2006.01); C07D 309/10 (2006.01); C07D 317/40 (2006.01); C07D 317/54 (2006.01); C07D 231/12 (2006.01); C07D 333/34 (2006.01); C07C 317/14 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 241/24 (2006.01); C07D 261/08 (2006.01); C07D 271/12 (2006.01); C07D 213/30 (2006.01); C07D 307/52 (2006.01); C07D 307/82 (2006.01); A61P 9/00 (2006.01);
U.S. Cl.
CPC ...
C07C 311/48 (2013.01); A61P 9/00 (2018.01); C07C 317/14 (2013.01); C07D 213/30 (2013.01); C07D 213/71 (2013.01); C07D 231/12 (2013.01); C07D 241/24 (2013.01); C07D 261/08 (2013.01); C07D 271/12 (2013.01); C07D 307/52 (2013.01); C07D 307/82 (2013.01); C07D 309/10 (2013.01); C07D 317/40 (2013.01); C07D 317/54 (2013.01); C07D 333/34 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07C 2601/08 (2017.05);
Abstract

The disclosed subject matter provides N-hydroxylsulfonamide derivative compounds of formulae (I), (II) or (III) as drawn below, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.


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