The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 09, 2018

Filed:

Oct. 11, 2016
Applicant:

The Johns Hopkins University, Baltimore, MA (US);

Inventors:

John P. Toscano, Glen Arm, MD (US);

Daryl A. Guthrie, Baltimore, MD (US);

Assignee:

The Johns Hopkins University, Baltimore, MD (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 319/06 (2006.01); C07D 239/62 (2006.01); C07D 231/22 (2006.01); C07D 231/46 (2006.01); C07D 231/08 (2006.01);
U.S. Cl.
CPC ...
C07D 319/06 (2013.01); C07D 231/08 (2013.01); C07D 231/22 (2013.01); C07D 231/46 (2013.01); C07D 239/62 (2013.01);
Abstract

The disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or development of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.


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