Johns Hopkins University

Cardioxyl Pharmaceuticals, Inc.

Daryl A Guthrie

John P Toscano

Frederick Arthur Brookfield

Vincent Jacob Kalish

Stephen Martin Courtney

Lisa Marie Frost

Carl Leslie North

Saghar Nourian

O-substituted hydroxamic acids with carbon-based leaving groups as HNO donors are disclosed. Pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions also are disclosed.

O-substituted hydroxamic acids

The disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or development of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.

Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as HNO donors

The disclosed subject matter provides pyrazolone derivative compounds, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

Pyrazolone derivatives as nitroxyl donors

N-substituted hydroxylamine derivatives with carbon-based leaving groups

The present disclosure provides N-hydroxylamino-barbituric acid compounds of formulae (1)-(4), pharmaceutical compositions and kits comprising them, and methods of using such compounds or pharmaceutical compositions. The present disclosure provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

Growing community of inventors

Baltimore, MD, United States of America

Daryl A Guthrie