Darell D Bigner

This inventor holds 56 USPTO granted patents and 26 published patent applications, plus 7 CIPO patents and 15 EPO patents, primarily in Immunotherapy Innovations (CPC class A61K). Top assignees: Duke University, Johns Hopkins University, The United States of America, as Represented by the Secretary, Department of Health and Human Services. Active years: 1993-2026.

USPTO Granted Patents = 56 (Patent Applications = 26)

% Patents Active = 91.1

CIPO Patents = 7

EPO Patents = 15 (Patent Applications = 22)

Average Co-Inventor Count = 3.7

ph-index = 12

Forward Citations = 406(Granted Patents)

Forward Citations (Not Self Cited) = 385(Dec 10, 2025)

Inventors with similar research interests:

Location History:

Chapel Hill, NC (US) (1993 - 1998)
Durham, NC (US) (2013 - 2020)
Mebane, NC (US) (1996 - 2023)

Company Filing History:

Johns Hopkins University

patents

11 out of 3,688

The United States of America, as Represented by the Secretary, Department of Health and Human Services

St. Jude Children's Research Hospital

patents

6. 1 out of 5,630

The University of Texas System

patents

7. 1 out of 8,743

US Government as Represented by the Secretary of the Army

patents

8. 2 out of 834,411

Other

patents

where one patent can have more than one assignee

Years Active: 1993-2026

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Areas of Expertise:

Immunotherapy

Oncolytic Poliovirus

Tumor Response Prediction

Immunotoxin

Genetic Alterations

Brain Cancer

Combination Therapy

Checkpoint Inhibitor

Antigen Presenting Cells

Bispecific Antibodies

Hotspot Mutations

Gliomas

56 patents (USPTO):Sort by Forward CitationsExplore Patents

1. 12514927 - IMMUNOTHERAPY WITH COMBINATION THERAPY COMPRISING AN IMMUNOTOXIN (2026-01-06),

2. 11813298 - Oncolytic poliovirus for human tumors (2023-11-14),

3. 11506666 - Detection of CD-155, the poliovirus receptor (2022-11-22),

4. 11428691 - Methods for predicting tumor response to immunotherapy (2022-08-30),

5. 11406677 - Oncolytic poliovirus for human tumors (2022-08-09),

6. 11331343 - Compositions and methods for activating antigen presenting cells with chimeric poliovirus (2022-05-17),

7. 11311628 - Production of immunotoxin D2C7—(scdsFv)—PE38KDEL (2022-04-26),

8. 11306364 - promoter mutations in gliomas and a subset of tumors (2022-04-19),

9. 11254988 - Somatic mutations in ATRX in brain cancer (2022-02-22),

10. 11065332 - Combination therapy of immunotoxin and checkpoint inhibitor (2021-07-20),

11. 10894987 - Genetic alterations in isocitrate dehydrogenase and other genes in malignant glioma (2021-01-19),

12. 10837064 - Genetic alterations in isocitrate dehydrogenase and other genes in malignant glioma (2020-11-17),

13. 10799543 - Oncolytic poliovirus for human tumors (2020-10-13),

14. 10744171 - Sequential anti-cancer treatment (2020-08-18),

15. 10744170 - Combination treatment (2020-08-18),

Title: Darell D Bigner - Pioneering Inventor from Mebane, NC

Introduction: Darell D Bigner is a renowned inventor hailing from Mebane, North Carolina. He has made significant contributions to the field of innovation and holds numerous patents in his name.

Latest Patents: Darell D Bigner's latest patents focus on advancements in medical technology, particularly in the areas of cancer research and treatment. His innovative solutions have the potential to revolutionize the way we approach healthcare.

Career Highlights: With a distinguished career spanning several decades, Darell D Bigner has established himself as a leading figure in the world of inventors. His work has been recognized globally for its impact and ingenuity.

Collaborations: Throughout his career, Darell D Bigner has collaborated with top researchers, scientists, and medical professionals to bring his inventions to life. His ability to work in multidisciplinary teams has led to groundbreaking discoveries in the field.

Conclusion: Darell D Bigner's passion for innovation and commitment to improving lives through his inventions make him a true pioneer in the world of inventors. His legacy continues to inspire future generations to push the boundaries of what is possible.