The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2022
Filed:
Jul. 14, 2020
Duke University, Durham, NC (US);
The Johns Hopkins University, Baltimore, MD (US);
Hai Yan, Durham, NC (US);
Bert Vogelstein, Baltimore, MD (US);
Nickolas Papadopoulos, Towson, MD (US);
Kenneth W. Kinzler, Baltimore, MD (US);
Yuchen Jiao, Columbia, MD (US);
Chetan Bettegowda, Lutherville, MD (US);
Darell D. Bigner, Mebane, NC (US);
Zachary J. Reitman, Durham, NC (US);
Patrick J. Killela, Durham, NC (US);
Duke University, Durham, NC (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
We surveyed 1,230 tumors of 60 different types and found that tumors could be divided into types with low (<15%) and high (≥15%) frequencies of TERT promoter mutations. The nine TERT-high tumor types almost always originated in tissues with relatively low rates of self renewal, including melanomas, liposarcomas, hepatocellular carcinomas, urothelial carcinomas, squamous cell carcinomas of the tongue, medulloblastomas, and subtypes of gliomas (including 83% of primary glioblastoma, the most common brain tumor type). TERT and ATRX mutations were mutually exclusive, suggesting that these two genetic mechanisms confer equivalent selective growth advantages. In addition to their implications for understanding the relationship between telomeres and tumorigenesis, TERT mutations provide a biomarker for the early detection of urinary tract and liver tumors and aid in the classification and prognostication of brain tumors.