The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2022
Filed:
Sep. 10, 2020
Applicant:
Duke University, Durham, NC (US);
Inventors:
Matthias Gromeier, Durham, NC (US);
John H. Sampson, Durham, NC (US);
Darell D. Bigner, Mebane, NC (US);
Annick Desjardins, Durham, NC (US);
Henry S. Friedman, Durham, NC (US);
Assignee:
Duke University, Durham, NC (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/768 (2015.01); A61K 9/00 (2006.01); A61K 41/00 (2020.01); A61K 45/06 (2006.01); A61K 51/08 (2006.01); A61N 5/10 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/768 (2013.01); A61K 9/0085 (2013.01); A61K 41/00 (2013.01); A61K 45/06 (2013.01); A61K 51/081 (2013.01); A61N 5/10 (2013.01); C12N 7/00 (2013.01); C12N 2770/32611 (2013.01); C12N 2770/32632 (2013.01); C12N 2770/32671 (2013.01); C12N 2770/32733 (2013.01); Y02A 50/30 (2018.01);
Abstract
Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. The mechanism of action is believed to involve both viral oncolysis as well as immune recruitment, both of which lead to necrosis in the area of the tumor. No adverse effects have been observed.