The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 20, 2021
Filed:
Nov. 04, 2016
Duke University, Durham, NC (US);
The Government of the United States As Represented BY the Secretary of Health and Human Services, National Institutes of Health, Rockville, MD (US);
Darell Bigner, Mebane, NC (US);
Vidyalakshmi Chandramohan, Durham, NC (US);
Smita Nair, Cary, NC (US);
Matthias Gromeier, Durham, NC (US);
Xuhui Bao, Durham, NC (US);
Ira H. Pastan, Potomac, MD (US);
Duke University, Durham, NC (US);
The Government of The United States as Represented by the Secretary of Health and Human Services, National Institutes of Health, Rockville, MD (US);
Abstract
Regional, tumor-targeted, cytotoxic therapy, such as D2C7-immunotoxin (D2C7-IT), not only specifically target and destroy tumor cells, but in the process initiate immune events that promote an in situ vaccine effect. The antitumor effects are amplified by immune checkpoint blockade which engenders a long-term systemic immune response that effectively eliminates all tumor cells.