Vidyalakshmi Chandramohan

Title: **Vidyalakshmi Chandramohan: Pioneering Innovations in Cancer Treatment**

Introduction

Vidyalakshmi Chandramohan, a prominent inventor based in Durham, NC, has made significant contributions to the field of medical research with a focus on cancer treatment. With a portfolio of four patents, her work is instrumental in advancing innovative therapies aimed at improving patient outcomes.

Latest Patents

Chandramohan's latest patents include a revolutionary assay for the detection of CD-155, the poliovirus receptor. This assay aids in the specific detection of CD155 in tissue sections, proving vital for its application in tumor types. The identification of CD 155 expression in glioblastoma cells correlates with the susceptibility of these cells to infection and destruction by PVSRIPO, a poliovirus construct. Furthermore, her patented anti-CD155 antibody allows mono-specific detection of CD155 through methods such as immunoblots and immunohistochemistry, which can guide the use of PVSRIPO in oncolytic immunotherapy for cancer.

Another notable patent is the production of the immunotoxin D2C7-(scdsFv)-PE38KDEL, which targets both wild-type and mutant epidermal growth factor receptors overexpressed in glioblastomas. Chandramohan has developed a Good Laboratory Practice (GLP) manufacturing process that allows for a robust production of D2C7-IT, which was instrumental for a Phase I/II clinical trial. Her innovative approach included expressing D2C7-IT under the control of the T7 promoter in a 10 L batch fermentation process, achieving a yield of over 300 mg of purified protein through sophisticated purification techniques.

Career Highlights

Throughout her career, Vidyalakshmi Chandramohan has been associated with distinguished institutions such as Duke University, where her research has been pivotal in cancer immunotherapy. Her collaboration with esteemed institutions like the United States of America as represented by the Secretary of the Department of Health and Human Services has further solidified her position in the biotechnology community.

Collaborations

Collaboration has been a cornerstone of Chandramohan's work. She has teamed up with notable coworkers such as Darell D. Bigner and Matthias Gromeier. Their collective expertise has fostered advancements that bridge the gap between laboratory research and clinical application, ultimately working towards effective cancer treatments.

Conclusion

Vidyalakshmi Chandramohan exemplifies the spirit of innovation in the medical field, particularly in her endeavors to combat cancer through groundbreaking research and patentable inventions. With her ongoing contributions and collaborations, she continues to inspire future generations of inventors and researchers dedicated to improving healthcare solutions.