The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2022
Filed:
Jun. 29, 2017
Applicant:
Duke University, Durham, NC (US);
Inventors:
Smita Nair, Durham, NC (US);
Michael Brown, Durham, NC (US);
Darell Bigner, Mebane, NC (US);
Matthias Gromeier, Durham, NC (US);
Assignee:
Duke University, Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 1/00 (2006.01); A61P 35/00 (2006.01); A61K 31/7105 (2006.01); A61K 35/76 (2015.01); A61K 39/00 (2006.01); A61K 39/39 (2006.01); A61K 45/06 (2006.01); A61K 35/15 (2015.01); A61K 9/00 (2006.01); A61K 35/14 (2015.01); C12N 5/0784 (2010.01); A61P 31/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/15 (2013.01); A61K 9/007 (2013.01); A61K 9/0043 (2013.01); A61K 9/0053 (2013.01); A61K 31/7105 (2013.01); A61K 35/14 (2013.01); A61K 35/76 (2013.01); A61K 39/0011 (2013.01); A61K 39/39 (2013.01); A61K 45/06 (2013.01); A61P 31/00 (2018.01); A61P 35/00 (2018.01); C12N 5/0639 (2013.01); A61K 2039/55561 (2013.01); Y02A 50/30 (2018.01);
Abstract
Chimeric poliovirus is capable of activating antigen presenting cells. The activation of the antigen presenting cells may be in vitro, ex vivo, or in vivo. The activated antigen presenting cells may be administered alone or with an antigen or vaccine. The activated antigen may be loaded in vitro or ex vivo with antigen to form antigen-loaded, activated, antigen presenting cells. These may be administered therapeutically. Therapeutic administration of antigen presenting cells may be used as an adjuvant to other therapies.