Xiang Yi

Title: Innovations of Inventor Xiang Yi

Introduction

Xiang Yi is a prominent inventor based in Foster City, CA (US), known for her significant contributions to the field of biotechnology. With a remarkable portfolio of 14 patents, she has made strides in developing innovative enzymes that have applications in pharmaceuticals and other industries.

Latest Patents

One of her latest patents involves engineered phosphopentomutase variant enzymes. This invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides with PPM activity, and polynucleotides encoding these enzymes. Additionally, it includes vectors and host cells that comprise these polynucleotides and polypeptides. The methods for producing PPM enzymes are also outlined in this patent. Furthermore, the invention offers compositions that include the PPM enzymes and methods for utilizing the engineered PPM enzymes, particularly in the production of pharmaceutical compounds. Another notable patent focuses on engineered glucose dehydrogenases and methods for the reductive amination of ketone and amine compounds. This application presents engineered glucose dehydrogenase polypeptides with imine reductase activity, polynucleotides encoding these engineered polypeptides, and host cells capable of expressing them. The methods described allow for the preparation of secondary and tertiary amine product compounds using a range of ketone and amine substrate compounds.

Career Highlights

Xiang Yi is currently associated with Codexis, Inc., where she continues to innovate and develop new technologies. Her work has been instrumental in advancing the capabilities of enzyme engineering, which has broad implications for various applications, including drug development.

Collaborations

Xiang collaborates with talented individuals such as Oscar Alvizo and James Nicholas Riggins, contributing to a dynamic research environment that fosters innovation and creativity.

Conclusion

Xiang Yi's contributions to biotechnology through her patents and work at Codexis, Inc. highlight her role as a leading inventor in the field. Her innovative approaches to enzyme engineering are paving the way for advancements in pharmaceutical production and beyond.