Company Filing History:
12 out of 1,651 
1 out of 480 
Years Active: 2002-2022
Title: Werner Hoelke: A Pioneer in Proteolytic Enzyme Innovations
Introduction
Werner Hoelke is a notable inventor based in Penzberg, Germany, recognized for his contributions to the field of proteolytic enzymes. With an impressive portfolio of 13 patents, Hoelke's innovations focus on the stabilization and preparation of solid compositions containing proteases, particularly those with applications in various industries such as pharmaceuticals and biochemistry.
Latest Patents
Among Hoelke's latest patents are methods for preparing solid compositions containing proteases. These innovative compositions, particularly lyophilizates, encapsulate proteolytic enzymes and present methods for their production. His compositions involve one or more proteases with collagenase activity alongside a neutral protease like thermolysin, distinguished for being free of acetate salts. Remarkably, these compositions exhibit enhanced solubility in water, surpassing conventional lyophilized protease mixtures.
Another significant patent focuses on enhancing the stability of thermolysin in aqueous solution, addressing the enzyme's common instability. In this invention, thermolysin, whether in crude form or as a lyophilisate, is treated with an aqueous buffer with low salt concentration to generate a stable solution of thermolysin. This innovative approach to stability is a substantial advancement in enzyme technology.
Career Highlights
Throughout his career, Werner Hoelke has been associated with prominent companies such as Roche Diagnostics Operations, Inc., and Roche Diagnostics GmbH. His work in these organizations has facilitated his extensive research and practical applications of proteolytic enzymes, enhancing their performance and reliability in various formulations.
Collaborations
Hoelke has collaborated with esteemed colleagues like Johann-Peter Thalhofer and Rainer Mueller. These partnerships have contributed to the advancement of their shared goals in enzyme innovation, establishing a strong foundation for success in their research endeavors.
Conclusion
Werner Hoelke's commitment to innovation in the realm of proteolytic enzymes is exemplified through his 13 patents, significantly influencing the industry. His latest inventions, emphasizing solubility and stability of proteases, reflect his dedication to enhancing the efficacy of enzyme applications. As a leading inventor in this field, Hoelke continues to pave the way for future discoveries and advancements in biochemistry.